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Peter Suber

There's a much simpler answer: Publish in the best journal that will accept your work; if that journal is not OA, then deposit a copy of your peer-reviewed manuscript in an OA repository. More than 60% of surveyed non-OA journals already give blanket permission for their authors to do this, and many others will permit it on request. Bottom line: there's rarely a trade-off between OA and conventional non-OA publication.

To see whether a given journal already gives this kind of permission, see the SHERPA database (or your own copyright transfer agreement).
http://www.sherpa.ac.uk/romeo.php

To find an OA repository where you could deposit your work, first see whether your university has an institutional repository. If it doesn't, then use a disciplinary repository.
http://oad.simmons.edu/oadwiki/Disciplinary_repositories

For more detail, see my article, Six things that researchers need to know about open access.
http://www.earlham.edu/~peters/fos/newsletter/02-02-06.htm#know

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